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This transgene was produced by microinjection of fertilized mouse oocytes with the yeast artificial chromosome (YAC) designated YRT3, which contained the tyrosinase gene from the normally-pigmented C3H mouse strain and its 5' flanking DNA through the locus control region (LCR) ~12 kb upstream of the gene, but lacked more 5' sequences. Expression of the transgene is demonstrated by its complete rescue of the pigment phenotype of albino (Tyrc/Tyrc) mice. This transgenic line has not been published. (J:223068)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
