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The transgene was designed with the mouse alpha myosin heavy chain (Myh6) promoter directing expression of a modified rat troponin I, cardiac 3 cDNA sequence followed by a human growth hormone (hGH) gene containing a polyA signal. The Tnni3 sequence contains a proline to serine substitution as residue 83 (P83S). This substitution mimics a known human sequence variant (P82S) found in 3% of normal African Americans. Founder line 270 was selected as the representative line. (J:265588)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
