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The targeting construct is designed to introduce a C420R point mutation (T2928C; TGT - CGT) into exon 8 of the gene with flanking loxP sites in introns 7 and 9. An FRT-flanked cassette containing the engrailed-2 strong splice acceptor and a reverse-orientation neomycin cassette under the control of the PGK promoter was also inserted immediately downstream of the intron 9 loxP site. (J:101977)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
