The human cDNA was placed behind a minimal CMV promoter and five tetracycline responsive elements. The construct was microinjected into the pronuclei of FVB/NCr embryos. The exogenous gene will only be expressed (in a tetracycline/doxycycline controllable manner) if mice containing this allele are crossed with mice containing a tTA or rtTA allele. (J:265381)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count