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The targeting construct is composed of an FRT site, EGFP, a loxP site, a neomycin cassette, and an FRT site upstream of exon 2. A second loxP is inserted site downstream of exon 2. Flp-mediated recombination removed the FRT-flanked EGFP and neo cassette leaving exon 2 floxed. Cre-mediated recombination removed exon 2. Immunoblot analysis confirms the absence of protein in the hippocampus. (J:263547)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
