Exon 2 was targeted using two sgRNAs and Cas9n (nickase version of Cas9). The result was an out-of-frame deletion (c.360_408del) that leads to a premature translation stop codon after 14 novel codons. (J:265366)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6J x (C57BL/6J x SJL/J)F1/J
Endonuclease-mediated
Intragenic deletion
--
1
4
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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