ENU-induced T to C transition at base pair 3,452,863 (v38) on chromosome 2, or base pair 28,802 in the GenBank genomic region NC_000068. The mutation corresponds to residue 1,259 in the mRNA sequences NM_146114 within exon 14 of 14 total exons. The mutation results in a leucine to proline substitution at position 391 (L391P) in the Artemis protein. (J:265131)