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Two in-frame nonsense mutations (TAA and TGA) were introduced into exon 1 using an sgRNA and a template oligonucleotide with CRSIPR/Cas9 technology. This mutation creates a p.L14X (p.Leu14Stop) mutation resulting in a severely truncated open reading frame. (J:264824)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
