Il4i1^H46-a

This minor histocompatibility antigen, initially identified as being between C57BL/10ScSn and 129/Rr but also found to be between C57BL/6J and 129P3/J, is caused by a single amino acid change at residue 25, which is alanine in C57BL/6J-derived H46-a and methionine for 129-derived H46-b. The 2 nucleotide sequence variations underlying this are G73A and C74T and the core antigenic peptide from each compete similarly for binding Ab. The core antigenic peptide in H46-a is HAFVEAIPELQ. (J:264442)