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With sgRNAs targeting the mu and gamma1 switch regions in the Igh-C immunoglobulin heavy chain constant region, the intervening sequence was deleted in ES cells using CRISPR/Cas9 technology. This engineered recombination (deleting the Ighm, Ighd, and Ighg3 segments) mimics an IgG1 class-switch. (J:252910)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
