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Starting with genomic DNA from the Del(2Hoxd1-Hoxd9)63Ddu allele, a 10 bp deletion (CCGACAGGCA) was created Using sgRNA 5'-AGAGCGTTAACCTCACCGAC,-3'. This deletion affects the coding region, introducing a frameshift and premature stop codon that replaces the last 34 amino-acids of the encoded peptide with 10 new amino-acids. This truncated peptide has a disrupted homeodomain with the third alpha-helix eliminated. (J:252916)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
