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A threonine to alanine change at position 175 (T175A) was introduced resulting in a kinase dead knock-in mutation. LoxP sites were introduced 3' and 5' to the targeted exons. A F3-flanked puromycin and FRT-flanked neomycin selection cassettes were removed via Flp-mediated recombination. (J:246310)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
