Two zinc-binding cysteine residues were substituted for two alanine residues located in the RING domain at positions 62 and 65 (C62A and C65A). A floxed neomycin resistance cassette was removed via cre-mediated recombination. (J:262172)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count