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EN
The targeting construct inserted into intron 4 a loxP site, alox2272 site, a reverse orientation modified exon 5 in which a nucleotide substitution (T to G) results in the amino acid substitution of alanine for serine at position 196 (S196A; ENSMUSG00000002108), and a loxP site. An additional lox2272 site was inserted downstream of the endogenous exon 5. Flp-mediated recombination removed the selection cassette inserted downstream of the modified exon 5. (J:263851)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
