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The transgene comprises the following elements: The mouse estrogen receptor 1 alpha promoter (4 kb genomic sequence upstream of ATG translation start), beta globin intron 1, the rtTA (reverse tetracycline-controlled transactivator) gene and SV40 poly(A) signal. This is part of the Tet-On system where mice double-transgenic for this transgene and a second transgene controlled by the tetO promoter express the second transgene in cells where the promoter of the first transgene is active when administered doxycycline. (J:254282)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
