Log In|Sign Up
EN
The alpha-MHC promoter drives the expression of the PKA-Calpha cDNA. Overexpression of the catalytic subunit results in constitutive activation of the enzyme without a requirement for cAMP. Assays for activity in heart extracts show that Prkaca activity is elevated 2.4-fold in line 33. (J:263774)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
