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The coding sequence for the first 173 amino-acids (containing the conserved DNA-binding domain) was replaced with a tdTomato fluorescent marker cassette. A loxP site, an FRT site flanked neomycin resistance gene cassette and a second loxP site were inserted into intron 1. The neo cassette was removed through subsequent cre-mediated recombination. This creates a knockout reporter allele, with the reporter gene expressed from the promoter of the targeted gene. (J:255683)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
