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The human U6 small nuclear RNA gene promoter was used to drive expression of a mouse anti-Cdk5 shRNA. The construct was microinjected into the male pronuclei of C57BL/6J zygotes. Three founders were generated. Immunohistochemical and Western blot analyses confirmed that protein expression was decreased in the skin of knockdown mice relative to wild-type controls. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:255707)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
