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The RP24-297F14 bacterial artificial chromosome (BAC), from the RPCI-24 mouse genomic library derived from a C57BL/6J male mouse, was modified by replacement of the sequence from the translation initiation site through the 3' untranslated region (3'-UTR) by the orthologous human sequence. A FRT site-flanked neomycin selection cassette was inserted ~1 kb downstream of the humanized 3'-UTR. This modified BAC was then used to target the endogenous mouse gene. (J:169366)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
