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The triplet CGG in exon was replaced by a TGT resulting in the replacement of an arginine with a cysteine at position 155 (R155C) and a floxed neo cassette was inserted in intron 4. Cre mediated recombination removed the neo cassette. The remaining loxP site is located further upstream than in mice carrying Vcp tm1.1Ccrs to avoid the splicing issue present in this allele. (J:263736)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
