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In an attempt to introduce a mutation into exon 5, a floxed neo cassette was introduced into intron 4 then removed via Cre mediated recombination. The presence of the remaining loxP site resulted in aberrant splicing and subsequent nonsense-mediated decay of the mutant mRNA. (J:228679)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
