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The donor constructed mice with a 0.9-Mb deletion on mouse chromosome 19 syntenic with the human 9p24.1 region by trans-allelic recombination in vivo. The deletion includes the genes Rln1, Plgrkt, Cd274, Pdcd1lg2, Ric1, Ermp1, Mlana, 9930021J03Rik, Ranbp6, Il33, Trpd52l3, Uhrf2, Gldc. Briefly, the donor inserted loxP sites into the mouse genome by targeting sites to flank the region to duplicate or delete. Mice were bred that carry the two loxP sites in trans and an Hprt-Cre transgene (RRID:IMSR_JAX:004302). (J:94077)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
