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The transgene comprises a 15.9-kb human genomic DNA fragment containing the wild-type allele of the rhodopsin gene with 4.8 kb of DNA upstream of the start codon and 6.2 kb of DNA downstream of the termination codon. Densitometric analysis of transgene-derived human and endogenous mouse rhodopsin mRNA-derived bands on autoradiographs of polyacrylamide gel-separated [alpha-32P]-dCTP-labeled RT-PCR products of retinal mRNA from heterozygous transgenic mice revealed a human:mouse transcript ratio of 1:1. (J:76722)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
