LoxP sites that flanked exons 2-6 were recombined via cre-mediated recombination, deleting these exons in the germline. Immnuoblotting analysis using testis extracts verified the absence of the encoded protein protein in homozygous mice. (J:250191)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count