The L1L2_Bact_P cassette was inserted at a position on Chromosome 12 upstream of exon 7 of the gene. The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site was inserted downstream of exon 7. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 7 floxed. (J:157065)
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cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count