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A transgene construct containing the following elements, in order, randomly inserted into the genome: the Tie2 promoter, a 1.3kb BamHI/NaeI Cx40 DNA segement, an IRES, the EGFP fluorescent reporter gene, a human growth hormone polyadenylation signal, and a Tie2 enhancer. The coding sequence of the inserted gene has an engineered A>T substitution at coding nucleotide 604 causing threonine codon 202 to change to a serine codon (p.Thr202Ser). This mutation is located in a conserved functional peptide sequence. (J:218811)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
