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The targeting vector was designed with a human MIR125B1 cDNA inserted between 2 splicing sites in the 3' untranslated region of an EGFP sequence and followed by a polyA signal. The targeting vector was then used to replace the Cre ORF in a mutant embryonic stem cell line (see note) and placed under the control of the tet response promoter (TRE). The construct was inserted into a cassette exchange locus upstream of the Hprt gene using Inducible Cassette Exchange (ICE) recombination. (J:240427)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
