The targeting vector contains a loxP-flanked STOP cassette, including a neomycin resistance (neo) cassette, upstream of the toll-like receptor 4 (Tlr4) gene. An internal ribosome entry site (IRES) fused to an enhanced green fluorescent protein (EGFP) sequence was inserted at the 3' end of Tlr4. (J:101977)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6N
Targeted
Insertion
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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