LoxP sites have been inserted into introns 1 and 3. A single FRT site in the 3' untranslated region (UTR), just 5' of the Pgk-neo cassette, marks the former site of a neomycin selection cassette that has been deleted by flp recombinase. Crossing mice bearing this allele with Cre recombinase-expressing mice will delete exons 2 and 3, which contain the entire homeodomain. (J:94077, J:260050)
Basic Information
(129S6/SvEvTac x C57BL/6J)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count