Log In|Sign Up
EN
The transgene consists of a mutant mouse cDNA, with an engineered substitution changing isoleucine codon 1127 into an alanine codon (p.Ile1127Ala), under the control of the mouse alpha myosin heavy chain promoter. Immunoblot assays indicate that the expression from this allele is around 5-fold higher than expression from the endogenous gene. The affected codon codes for the isoleucine crucial for the actin binding function of the peptide. (J:262067)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
