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The targeting cassette contains CAG-loxP-(PGK-neomycin - 4x polyA) Stop-loxP-biotin ligase recognition peptide (BLRP)-3x FLAG-LSD1 WT-IRES2-EGFP-4x polyA. The LSD1 VN (KDM1A) insertion expresses a FLAG-tagged full-length human KDM1A cDNA, which encodes an 852 amino acid isoform of the gene that includes a 60 nucleotide exon in intron 2 (E2a) as well as an EGFP fluorescent reporter. (J:101977)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
