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The targeting construct inserted into the locus a CAG promoter, loxP-flanked transcriptional STOP cassette, and a mutant mouse Slc39A14 with a T to G mutation at position 1535 resulting in a lucine to arginine substitution at amino acid 438 (L438R). Cre-mediated recombination is necessary to remove the STOP cassette and get expression of the mutant protein. (J:261326)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
