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A loxP site and an FRT-flanked PGK-neomycin cassette (in reverse transcriptional orientation) are placed in intron 3 along with a loxP site in intron 7 (thus flanking exons 4-7 with loxP sites). In addition, an Arg215His (R215H amino acid; G644A nucleotide) mutation is introduced to exon 4 of the gene. Flp-mediated recombination removed the FRT-flanked neo cassette. The Arg215His (R215H) loss-of-function point mutation in the human gene has been identified in schizophrenia patients. (J:101977, J:272181)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
