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The targeting vector was obtained from the KOMP repository at UC Davis and is composed of an FRT site followed by lacZ sequence and a loxP site. The first loxP site is followed by neomycin resistance gene, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 3. The critical exon 3 is thus flanked by loxP sites. Cre-mediated recombination removed the neomycin gene and exon 3, resulting in a reporter knockout mouse. Western blot confirmed absence of protein in the brain and kidney. (J:244278)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
