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The transgene is comprised of mouse Pomc sequences from -13.3/-6.8 and -2.1/+3.2 kb, numbered relative to the transcriptional start site, ending within the 5 untranslated region of exon 2. This promoter region contains regulatory elements, which include distal 5' neural enhancer elements. This promoter drives expresion of an obligate dimerized form of DsRed (tdimer2(12)). SV40T-antigen poly(A) sequences are included at the 3' end of the construct. Two separate founder lines were initially analyzed (lines 17 and 18). Line 18 was studied further and distributed. (J:214650)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
