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The transgenic construct consists of the tetO, tetracycline-responsive regulatory element (from pTRE-tight), cDNA encoding the Drosophila AstA-R1, or AlstR, allatostatin A receptor 1, gene and a SV40 polyadenylation sequence. The TRE promoter used here is Tet-responsive Ptight; containing a modified Tet response element composed of seven direct 36 bp repeats (each containing the 19 bp tet operator sequence) and a minimal human cytomegalovirus promoter, which lacks the enhancer that is part of the complete CMV promoter. Consequently, Ptight is silent in the absence of TetR or rTetR binding to tetO. (J:261666)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
