A loxP site was inserted upstream of exon 8 and a loxP site and a FRT-flanked neomycin cassette were inserted downstream of exon 8 in opposite orientation. Flp-mediated recombination removed the selection cassette leaving exon 8 floxed. (J:243531)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count