This TALEN-mediated null mutation has a 61 bp deletion in exon 2, Chr 17: :34264928-34264988 (GRCm38), followed by 39 bp of retained endogenous sequence, then a 507 bp deletion, Chr 17: 34265028-34265534, with a 7 bp insertion (CCGTCAC) in its place, the impact of which is a disruption of most of exon 2. Flow cytometric analysis confirmed this to be a null allele. (J:268035)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
NOD.Cg-Prkdcscid H2-K1b-tm1Bpe H2-D1b-tm1Bpe Il2rgtm1Wjl/Sz
Endonuclease-mediated
Insertion, Intragenic deletion
Not Specified
1
8
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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