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A targeting vector was designed to insert a FRT site followed by an splice acceptor (SA) fused to the internal ribosomal entry site (IRES) and a lacZ gene, a loxP site, a neomycin resistance gene cassette, a second FRT site and a second loxP site (FRT-lacZ-loxP-Neo-FRT-loxP) intron 1 and a third loxP site immediately downstream of the exon2. Cre-mediated recombination removed the neo cassette and exon 2 from Sp9tm1Zyan leaving lacZ casset under control of endogneous promoter of Sp9. This is a null allele. (J:238868)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
