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LoxP sites were inserted to flank exon 1. An frt-flanked neomycin selection cassette was also inserted 3' to exon 1. Cre-mediated recombination of the loxP sites resulted in a deletion of exon 1 and the neomycin selection cassette. Western blot analysis confirmed the absence of encoded protein in T cells from homozygous mutant mice. (J:259093)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
