A loxP site was inserted downstream to exon 4 and a loxP-frt-flanked Neomycin selection cassette was inserted in intron 3, upstream of exon 4. Cre-mediated recombination removed the neomycin cassette and exon 4. (J:259798)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count