Samd7^tm1Tfur

Exons 4-6 were replaced with a loxP site flanked neomycin selection cassette. This is predicted to cause a a premature stop codon due to a frame shift, resulting in a truncated peptide that would lack the SAM domain. Absence of mRNA and protein expression from this allele in homozygous mice was confirmed by RT-PCR and Western blot, respectively. (J:253631)