CRISPR/Cas9 technology was used to mutate cysteine 121 within the UBR domain in exon 3 to a premature stop codon. Western blot analysis confirmed absence of protein in P16 testes. (J:243410)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6 x CBA)F2
Endonuclease-mediated
Nucleotide substitutions
--
1
1
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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