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A FRT-LoxP-Neomycin-FRT-LoxP selection cassette was inserted downstream of exon 4 and the third single LoxP site was inserted upstream of exon 4. The region flanked by the second and third LoxP sites is approximately 569 bp. Exon 4 encodes amino acids 337-386 and deletion of this sequence results in the creation of a premature stop codon. The neomycin selection cassette was removed via FLP-mediated recombination, leaving loxP sites flanking exon 4. (J:259070)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
