Parental line mouse Grntm1Blrl consisting of a loxP site inserted upstream of exon 3 and a cassette containing (5' to 3') a loxP site, FRT site, splice acceptor, IRES, beta-geo cassette, stop codon, polyadenylation sequence, and FRT site inserted downstream of exon 4 was crossed with Flp-deleter to remove the cassette leaving loxP flanked exons 3 and 4. The mice was further crossed with cre-deleter to remove exon 3 and 4, resulting in constitutively null mice. (J:211725)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/SvImJ
Targeted
Intergenic deletion
--
1
9
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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