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Transgenic mice overexpressing wild-type human neuroserpin under the control of the mouse Thy1 promoter were generated by pronuclear injection into fertilized oocytes using an expression cassette derived from the murine Thy1 gene. The transgene was expressed in central nervous system neurons throughout postnatal life. The expression levels for transgenic mice overexpressing human Syracuse neuroserpin were for transgenic mice with human wild-type neuroserpin 5.9 times above the endogenous neuroserpin level of wild-type mice. (J:120135)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
