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The Venus reporter was inserted in-frame before the stop codon in BAC clone RP24-333G17. A fully functional fusion protein expressed from this construct was capable of rescuing the Lrrc6 null lethal phenotype. The Lrrc6::Venus protein was localized in the cytoplasm of E8.0 node cells but not in the axoneme of node cilia. Similarly, the fusion protein was localized only in the cytoplasm of tracheal epithelial cells and primary spermatocytes and spermatids in the testis. (J:258369)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
