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The Fcgr2b gene promoter in a set of autoimmune-prone mice was shown to be disrupted by a a 13 bp deletion interrupting two putative transcription factor binding sites, an AP4 site and an S box. Strains and strain families that carry this mutations include NZB, BXSB, SB/Le, MRL, NOD and 129. In addition, NZB has seven As from 247 to 242 instead of 6 (NZW) or 5 (CON); NOD has a T at 21 (as does NZW) instead of a C. (J:79651)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
