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The transgenic construct contains a rat enolase 2, gamma neuronal (Eno2) promoter, containing a random filler sequence and an SV40 polyadenylation signal, directing expression of human matrix metallopeptidase 9 (MMP9) cDNA. The MMP9 gene was modified to harbor a glycine to leucine mutation at residue 100 (MMP9*G100L), in the cysteine switch autoinhibitor region, rendering the enzyme constitutively active. Of the five lines, founder line exhibits the highest transgene activity. (J:258077)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
