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The transgenic construct contains a composite human albumin (ALB) promoter, containing a 235 bp SV40 enhancer element and a 213 bp albumin promoter element, directing expression of human proprotein convertase subtilisin/kexin type 9 (PCSK9) cDNA, followed by a C-terminal V5 tag. A chimeric intron (from pRL-SV40) was inserted between the promoter and PCSK9 cDNA to enhance expression. The transgene expresses primarily in the kidney. (J:158079)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
